Page 91 - Portuguese Journal - SPORL - Vol 61. Nº1
P. 91

Proposal for review of UNHS in Portugal           for auditory neuropathy, and noise exposure in
                                                            the NICU may also contribute to hearing loss.
                                                                                                         6
          1. Risk factors to be included (Table 1)          EUSCREEN  suggests  that this  group should
          a) Parental consanguinity                         be assessed by AEP. 5
          Population studies conducted in the Middle        It should be noted that the Société Française
          East  have  shown  the  existence  of  up  to  3.5   de Pédiatrie also suggests the inclusion of
          times more cases of childhood hearing loss        preterm infants under 32 weeks of gestation
          in the offspring of blood-related couples.   16,17    in the at-risk group, as well as those with
          Therefore, it is pertinent to include NBs  of     brain complications related to prematurity  .
                                                                                                        13
          blood-related couples in the at-risk group for    Because this is a controversial issue due to the
          UNHS in Portugal.                                 overlap between this group of NBs and NBs
                                                            requiring NICU admission or those exposed to
          b) Intrauterine Zika virus infection              other risk factors that were already included in
          NBs with  intrauterine Zika virus  infection      the at-risk group  27-29 , we chose not to include
          (mother with laboratory findings of Zika virus    this risk factor as an isolated factor.
          infection during labor and NBs with laboratory
          confirmation of infection) should be included     e) ECMO
          in the at-risk group for UNHS according to        Children undergoing ECMO were included
          the recommendation of the JCIH  , even            by the JCIH due to the increased risk of late-
                                                6
          when asymptomatic. This risk group should         onset hearing loss. 3,6,14
          preferably be evaluated using AEP. 6
                                                            f) Fetal Alcohol Syndrome
          c)  Intrauterine  exposure  to  toxic  substances   The Société Française de Pédiatrie recommends
          and/or tobacco                                    the inclusion of all NBs with documented
          Following the guidelines of the Société Française   intrauterine exposure to alcohol . Despite the
                                                                                           13
          de Pédiatrie, all NBs with intrauterine exposure   association shown between fetal alcohol
          to tobacco and/or toxic substances were           syndrome and childhood hearing loss        30,31 ,
          included. Some studies have demonstrated          studies conducted in recent years on children
          that NBs exposed to tobacco during                diagnosed with diseases of the fetal alcohol
          pregnancy had lower amplitudes of OAE     18,19 .   spectrum did not demonstrate an increased
          Intrauterine exposure to tobacco was recently     prevalence of hearing loss in this population
          associated with an increased risk of hearing      compared to healthy children . However, we
                                                                                          32
          loss in childhood   and adolescence.              deemed that NBs diagnosed with fetal alcohol
                                               21
                           20
          Intrauterine exposure to toxic substances such    syndrome should be included in the at-risk
          as cocaine and/or opioids has been shown to       group of hearing loss.
          be associated with worse auditory outcomes
          in several studies.  22–26                        g) Ventriculoperitoneal shunt
                                                            Recent evidence suggests that 40% of children
          d)  Hospitalization  in  the  Neonatal  Intensive   (18 years old and less) develop hearing loss of
          Care Unit (NICU) longer than five days            at least 15 dB in three consecutive frequencies
          All NBs admitted to NICUs for more than           after ventriculoperitoneal shunt placement. 33,34
          five  days  should  be  included,  regardless  of   For this reason, EUSCREEN suggests that
          whether they underwent invasive mechanical        all children should be considered at risk of
          ventilation, as suggested by the JCIH. An         hearing  loss  after  ventriculoperitoneal  shunt
          association between this population and the       placement and have their hearing evaluated
          increased risk of auditory neuropathy has         in accordance with their ability to collaborate. 5
          been established.  The use of aminoglycosides
                           6
          and hyperbilirubinemia are known risk factors



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