Page 86 - Portuguese Journal - SPORL - Vol 61. Nº1

Table 2
Results of the meta-analysis comparing the intervention and placebo groups for the parameters
evaluating the response to treatment with monoclonal antibodies in chronic rhinosinusitis with nasal
polyps

Evaluated Study or Intervention Group Placebo Group Mean Difference;
Parameter Subgroup Mean, IV, Random,
Mean Standard Total Mean Standard Total 95% CI
Deviation Participants Deviation Participants
DUPILUMAB
Until 24 weeks
Bachert 2016 (a) 12.8 11 30 30.2 19.6 30 -17.40 [-25.44,-9.36]
LIBERTY SINUS 24 18.58 14.92 143 40.49 23.06 133 -21.91 [-26.53,-17.29]
LIBERTY SINUS 52 23.89 23.89 295 42.16 23.26 153 -18.27 [-22.53,-14.01]
Subtotal (95% CI) 468 316 -19.61 [-22.53,-16.69]
Heterogeneity: Tau =0.00; Chi =1.62, df=2 (P=0,.44); I =0%
2
2
2
Test for overall effect: Z=13.17 (P<0,.00001)
SNOT-22 Until 52 weeks
LIBERTY SINUS 52 21.67 19.16 150 44.05 22.66 153 -22.38 [-27.10,-17.66]
Subtotal (95% CI) 150 153 -22.38 [-27.10,-17.66]
Heterogeneity: Not applicable
Test for overall effect: Z=9.29 (P<0,.00001)
Total (95% CI) 618 469 -20.38 [-22.86,-17.89]
2
2
Heterogeneidade: Tau =0.00; Chi =2.58, df=3 (P=0,.46); I =0%
2
Test for overall effect: Z=16.08 (P<0,.00001)
2
Test for differences between subgroups: Chi =0.96, df=1 (P=0,.33); I =0%
2
Until 24 weeks
Bachert 2016 (a) 4 1.9 30 5.4 1.5 30 -1.40 [-2.27,-0.53]
LIBERTY SINUS 24 3.75 1.98 143 5.94 1.44 133 -2.19 [-2.60,-1.78]
LIBERTY SINUS 52 4.46 1.89 295 6.09 1.19 153 -1.63 [-1.92,-1.34]
Subtotal (95% CI) 468 316 -1.80 [-2.25,-1.35]
Heterogeneity: Tau =0.10; Chi =5.70, df=2 (P=0,.06); I =65%
2
2
2
Test for overall effect: Z=7.87 (P<0,.00001)
NPS Until 52 weeks
LIBERTY SINUS 52 3.76 2.2 150 6.1 1.52 153 -2.34 [-2.77,-1.91]
Subtotal (95% CI) 150 153 -2.34 [-2.77,-1.91]
Heterogeneity: Not applicable
Teste para efeito geral: Z=10.75 (P<0,.00001)
Total (95% CI) 618 469 -1.94 [-2.36,-1.52]
Heterogeneity: Tau =0.12; Chi =10.73, df=3 (P=0,.01); I =72%
2
2
2
Test for overall effect: Z=9.10 (P<0,.00001)
Test for differences between subgroups: Chi =2.94, df=1 (P=0,.09); I =65.9%
2
2
Until 24 weeks
Bachert 2016 (a) 9.4 5.1 30 17.9 5.7 30 -8.50 [-11.24,-5.76]
LIBERTY SINUS 24 10.89 4.82 143 18.97 4.51 133 -8.08 [-9.18, -6.98]
LIBERTY SINUS 52 12.86 3.87 295 17.73 3.81 153 -4.87 [-5.62, -4.12]
Lund Mackay Subtotal (95% CI) 468 316 -7.00 [-9.61,-4.39]
Score
Heterogeneity: Tau =4.64; Chi =25.69, df=2 (P<0,.00001); I =92%
2
2
2
Test for overall effect: Z=5.25 (P<0,.00001)
Total (95% CI) 468 316 -7.00 [-9.61,-4.39]
Heterogeneity: Tau2=4.64; Chi2=25.69, df=2 (P<0,.00001); I2=92%
Test for overall effect: Z=5.25 (P<0,.00001)
Test for differences between subgroups: Not applicable
86 Portuguese Journal of Otorhinolaryngology - Head and Neck Surgery