Page 49 - Portuguese Journal - SPORL - Vol 61. Nº2
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Table 7
Primary treatment modalities
Treatment Number of patients (%)
Surgical treatment 16 (84.2%)
Surgery alone 4 (21.1%)
Surgery + radiotherapy 10 (52.6%)
Surgery + chemoradiotherapy 2 (10.5%)
Non-surgical treatment 3 (15.8%)
Radiotherapy 1 (5.3%)
Chemoradiotherapy 1 (5.3%)
Chemotherapy 1 (5.3%)
Table 8
Histology, initial TNM staging and local of recurrence for patients with recurrent disease
Histology Staging (TNM) Recurrence
Local (premaxillary skin, maxillary bone, hard
Squamous cell carcinoma T1N0M0
palate, nasal cavity floor)
Neuroendocrine tumors T4bN0M0 Distance (epicranium)
Mucosal malignant melanoma T3N0M0 Distance (lung)
Mucosal malignant melanoma T3N1M0 Local (hard palate)
Adenoid cystic carcinoma T4bN0M0 Distance (lungs)
(range from 2-71 months). Recurrent disease = 0.025, figure 1a), as well as DFS (p = 0.025,
occurred in 5 patients (26.3%), being local in 3 figure 1b). While patients with T3, T4a or T4b
patients and metastatic in 2 patients. In table tumors had worse prognosis compared with
8 is summarized the histology, initial TNM T1 patients, the difference was not statistically
staging and the local of recurrence. significant (p = 0.092, figure 1c). Primary
Five-year overall survival (OS) was 53.5% and treatment modality significantly influenced
disease-free survival (DFS) was 62.8%. History survival (p = 0.002), with surgical therapy
of previous tumors was statistically associated showing a statistically significant difference
with worse prognosis (p < 0.001), while smoke compared to nonsurgical treatments (p < 0.001).
(p = 0.733), alcohol consumption (p = 0.205) or In patients submitted to surgical treatment,
occupational risk factors (p = 0.584) did not there was no statistically significant difference
affect prognosis. Patients with nonepithelial in 5-year OS between external approach and
tumors had worse prognosis compared with endonasal endoscopic approach (p = 0.724).
patients with epithelial tumors, despite the Although the presence of microscopically
difference was not statistically significant (p positive margins was associated with worse
= 0.230). N component of TNM staging for prognosis, the difference was not statistically
epithelial and mucosal melanoma tumors significant (p = 0.123).
significantly affected 5-year OS, with positive
nodes associated with worse prognosis (p
Volume 61 . Nº2 . June 2023 191
