Page 46 - Portuguese Journal - SPORL - Vol 61. Nº2
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beyond their bony confines, being diagnosed excluded basal cell carcinoma, squamous cell
in later stages. In addition, the complex carcinoma (SCC) and melanoma of the nasal
anatomy of the sinonasal region and proximity pyramid, because they are generally managed
of critical structures such as the orbit, in the dermatology department .
3
brain, or cranial nerves, further complicates
management of these patients and leads to Statistical analysis
frequent local relapses and eventually death . Statistical analysis was performed with SPSS
6,7
Comparison of results between different 24.0 for windows (SPSS Inc., Chicago, IL,
institutions is limited due to the rarity of USA). For overall survival (OS), the follow-up
these tumors, the presence of many different time was defined as the time between initial
histologic subtypes and the advanced stage presentation at this institution for the tumor
at the diagnosis . of interest and the last appointment or death.
8
The purpose of this study was to characterize For disease-free survival (DFS), the follow-up
the demography, risk factors, clinical time was defined as the time between the
presentation, histologic types, management, conclusion of treatment for the primary tumor
and survival of patients with malignant tumors until the date of the first recurrence, death, or
of the nose and paranasal sinus treated at a last contact.
tertiary hospital center in Portugal. Quantitative variables were expressed as
mean ± standard deviations or as median
Materials and Methods ± interquartile range for data not normally
The study was conducted at Otolaryngology distributed. Qualitative variables were
department of the Centro Hospital de Lisboa expressed as absolute values and percentages.
Ocidental, a Portuguese tertiary center. Kolmogorov-Smirnov and Shapiro Wilk
The clinical records of patients with malignant normative tests were used in order to access
tumors of the nose and paranasal sinuses distribution pattern in quantitative variables.
were retrospectively reviewed through the Student’s t test, A-nova one way and
Information Systems and Technologies respective non-parametric tests, χ2 and proper
Service (SSTI) of the Centro Hospitalar de adjustments were used to relate evaluated
Lisboa Ocidental. All patients with these variables with primary outcomes (death and
malignancies, from January 2012 to December recurrence). Kaplan – Meyer curves were used
2021, were included. to determine 5-year OS and DFS and qualitative
The following data was collected: variables were compared regarding survival.
demographics (age, gender, occupation), A p value < 0.05 was considered statistically
habits (smoking, alcohol), clinical presentation, significant.
location, staging (according to the 8 edition of
th
American Joint Committee on Cancer (AJCC) Results
on epithelial tumors of the nose and paranasal From January 2012 to December 2021, 19
sinuses and mucosal melanoma), histology patients were included in our study (table 1).
(based on the 4 edition of World Health The patients were predominantly males (11
th
Organization (WHO) classification of tumors), patients, 57.9%), with a mean age at diagnosis
treatment, residual disease, recurrent disease, of 66.7 ± 9.8 years (range between 51 and 89
five-year overall survival (OS) and disease-free years). Ten patients (52.6%) were smokers and
survival (DFS) 9, 10 . 6 (31.6%) had alcoholic habits. Four patients
We excluded nasopharyngeal tumors because (21.1%) had occupational risk factors (2 wood
they have a different etiology, originating workers, 1 working in textile industry and 1
from epithelial and b-cell interactions of the working with chemical compounds) and 2
nasopharynx, and the primary treatment patients (10.5%) had history of previous tumors.
in most cases is not surgical. We have also The most common presenting symptoms
188 Portuguese Journal of Otorhinolaryngology - Head and Neck Surgery
