Page 21 - Revista Portuguesa - SPORL - Vol 39. Nº2

Rev Port. ()RL Vol. n."3‘). n." .). pp. IjI-Ij'). 200]

Anigo Original

FACTORES DE PREDISPOSIÇÃO GENÉTICA PARA CARCINOMA
ESPINOCELULAR DA LARINGE:
A IMPORTÃNCIA DOS POLIMORFISMOS METABÓLICOS

Groço Vorzim'. Eunco Monteiro". Regino Suvo'.
Carlos Pinheiro'fl Machado Aires". Ccnos Lopes'

Who
Us (.m'munus npumx‘clulm‘s (LI larmgc ("lhllllk'nl .“ "('anst mm Irrqm'nlcs (h Im In .u‘mdmcsmn \upcru rr wndu u ulum
c u .Iluml rrumlx'cxhn .Igrnu's can'mugclm'm .nsux'udm .m (k'wmnh mK-mn drsu' "pn dc lum- vr h ('n/mus dc law I rcprrscnudn
mmmurunwmc pd" slsll'uu ( .mx'mmu P050. .u'uum mcuholu .unculc pnu .m mc rgc-nrm mm. ungcm .| mlcrnx-dun—n ruunm
(nm gnndr .nmuhdr pot nurmnmk-(ulus ( ('IuIm-s l'ur uulrn Lulu .» ('n/mm (k' Lm- II n'pn'wnunhs pcln chnu d.: (.quunm \
lrunslcnw (' N aq'clnllunslcruw. umplwm run mlcrnx-dumn J (i'm .nlm « »Imns nu Amu u rmpk-undn .uscm . » wu ( x In dv.- clmmug .m
l' \Ncm Intuºs n uk'm'm (k' que .As (llk'rcnus gt‘m-Iu .» ":an .|— .I rrgung JU ('xpn'sun r .u m xhdr d- n gcnn u xhlx .ul- rrcs dr ('n/mus
cm. nh uhsmnm14lmhsnunk “ºn. nhmuu n. u "Nluum Lu lun's ( nuuls [um .| drunk.“ , (k' um (1mlnlxhdr (um- mal r (1cm » ( .m m vgcnxn
(lm qumuun .lmhu'nuls lin ohpu'mn (k'slc umd" (k'u'rnmur .| mllucm u (k' (k-u-rmmnus lufnu— pullmurlun dm guru ( ) I’I II
( )I'JIX», ( ”'1! I. (AI lll. (AI'I !. (AII'I. Null I c \.|I.‘ nu prmcsw dr unu'nuuu d; Lmngc
Poiovvos-Chavo: Pohmorhsmos melobohcos suscepmuhondw ()(-enem” 1,9" .'v_,»r' .* ':sg.«'»w»:—,w;' i: ";**—gi:

Summary
\quumnm ( l‘” ( cm mumu n] !In' larynx n llu- mm! [rrqm-nl 'na/mmm: | n/ [hr “]:/mr rm/nmlun .:ml dlgnlu (' Inn I ( l_uurc'lh'
unnL'ng und « hrmm uh nim! ( nmum/tlmn un- mluthIu-d duu- :lv/x-mlc-nl 4 mmuu (' [m Inn unm mlnl In !Iu- dv: rln/nm-nl n/ [hn
L'lml n] lumnr I’IIuM- I rnzrmm, n'lm'u'nlwl hr ( Hm hrmm' l' l 5!! m In an- rm-Iulmluulh [mx un mugc-ru In m-rmmxu «'In lrn/Jlulu
Hlll'fnlc'dl‘lll‘\ m: Ilu- uIIu-r hum], [rim.u' II «:::|-mm. IIL-v (,Iululhlum- \ lmmlc-mu' uml \ ulu‘llllnlIh/vnlu‘ um/uguh' !ln-w
mlrrmmllulm In uwh-r mluhh- dvruulm ( nm/tlvlmg Ilu' lll’IlI.\‘l/IUIIIUII 4 “Ir Iln-n' n gnnd w nlwu «' Um! ;.gmwlu (II]lc-n-m m m Ihr
mwllulmn. ur/mmmn mu] m IIl'lll' n] gvnm uullng [ur [vlww I and [thaw II m:) mm u uuld Ix- . rm ml [m Inn m dc/mmg «um rr
unu'pllhllllr uml um mngwm [~un-r u] mm! vm-Irnmm'ulu/ 'In-"mul— Ihr mm n/ Hm \Imh um In mmhw !ln' n-qunmlup
lx-lm'vn wu-mlgu-m-m [mlrmnr/Iluum. 1m lmlmg ( H'Ivll ( )I'JIN- ( )I‘.’l I (.\I lll (.sl'll (.sll'l \ III .nul \ II.’g.-m-\ um]
Ihc mk u] xln-ru'ln/mm .sqmmmm ( c'll (un mmm: n/ llu' Iarrln
Koy-Wovdt Mcªmholw ;wimvphlsms genehc suscwwlw '. Sd., run,; & z» :: "1: M ' J'."-

lntroducéo celulares; (' m (Iarcinugc‘ncm lndircctos. quc
Muitas alterações celulares ck'vcm-scílacçán para acluarcm necessitam de activação mcla-
dc agente.» quimicns sobre genus rcguladnrcs huh'ca dcpcndcmc de sistemas enzimático»
alvnsusccptivcis. [isles ugcntcsu'micus pudcm cunlmladus geneticamente. A maioria dos
dividir—wcmduns classes principais: os(íurcinu químicas assucindns a carcinogéncw (" cum-
g(ºncns Dircclus. que têm cupncidadc dc inlc- pmlu por pequenas nmlu‘ulas liptmlicas. quc

racluar directamente cum os cumpuncnlcs necessitam dcwfrcr activagfiumctabOlica para

' l nuhdc dc ()nculngu Molecular du &"ku dc Anamnna I'alulugnu
" M'rng'u dc (nnrrmc)lurlngulugu
Insmmu I’nrlugués dc ()nculngu Francisco (.cnul - ( cnlm dn Purln

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