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recent Literature, our results suggest that followed are in accordance with the regulations
PRP injection into the olfactory mucosa is established by the directors of the Commission
an innovative, safe and effective approach for Clinical Research and Ethics and in
to improve olfactory recovery. Therefore, this accordance with the Declaration of Helsinki of
study reinforces the determinant role of the the World Medical Association.
Otorhinolaryngologist in the treatment of
olfactory complaints. Nevertheless, despite Privacy policy, informed consent and Ethics
promising results, further research is needed committee authorization
to confirm the effectiveness of PRP in olfactory The authors declare that they have obtained
mucosa regeneration, and to establish optimal signed consent from the participants and that
protocols for PRP preparation and injection they have local ethical approval to carry out
technique. More studies with larger sample this work.
sizes and extended follow-up periods could
help to fully understand its potential benefits Financial support
and to standardize the treatment approach. This work did not receive any grant contribution,
funding or scholarship.
Acknowledgments
We want to thank Dr. André Varandas Borges Scientific data availability
from the Physical Medicine and Rehabilitation There are no publicly available datasets related
Department of Centro de Reabilitação to this work.
do Norte who promptly transmitted his
knowledge about PRP usage into our practice. References
Also, to Dr. João Carvalho Almeida from the 1. Sousa FA de, Machado AS, da Costa JC, Silva AC, Pinto
Otorhinolaryngology Department of Centro AN, Coutinho MB. et al. Tailored approach for persistent
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his knowledgeable advices, support of the doi: 10.1177/00034894221111093.
work, and aid in graphic illustration. We would 2. Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van
den Berge K, Gong B. et al. Non-neuronal expression of
also like to express the deepest gratitude SARS-CoV-2 entry genes in the olfactory system suggests
towards the consultation head nurse Paula mechanisms underlying COVID-19-associated anosmia.
Lamas and her team for the unwavering Sci Adv. 2020 Jul 31;6(31):eabc5801. doi: 10.1126/sciadv.
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3. Bénézit F, Le Turnier P, Declerck C, Paillé C, Revest
the authors´ Department who assisted the M, Dubée V. et al. Utility of hyposmia and hypogeusia
interventions. We are profoundly thankful to for the diagnosis of COVID-19. Lancet Infect Dis. 2020
Dra. Cecília Almeida e Sousa for her guidance Sep;20(9):1014-1015. doi: 10.1016/S1473-3099(20)30297-8.
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Conflict of Interests 5. Lechien JR, Chiesa-Estomba CM, Beckers E, Mustin
V, Ducarme M, Journe F. et al. Prevalence and 6-month
The authors declare that they have no conflict recovery of olfactory dysfunction: a multicentre study of
of interest regarding this article. 1363 COVID-19 patients. J Intern Med. 2021 Aug;290(2):451-
461. doi: 10.1111/joim.13209.
Data Confidentiality 6. Printza A, Katotomichelakis M, Metallidis S,
Panagopoulos P, Sarafidou A, Petrakis V. et al. The clinical
The authors declare that they followed the course of smell and taste loss in COVID-19 hospitalized
protocols of their work in publishing patient patients. Hippokratia. 2020 Apr-Jun;24(2):66-71.
data. 7. Tan BKJ, Han R, Zhao JJ, Tan NKW, Quah ESH, Tan
CJ. et al. Prognosis and persistence of smell and taste
dysfunction in patients with covid-19: meta-analysis with
Human and animal protection parametric cure modelling of recovery curves. BMJ. 2022
The authors declare that the procedures Jul 27;378:e069503. doi: 10.1136/bmj-2021-069503.BMJ.
8. Patel ZM, Holbrook EH, Turner JH, Adappa ND, Albers
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