Page 15 - Portuguese Journal - SPORL - Vol 61. Nº2

Clinical evaluation protocol for chronic

rhinosinusitis with polyposis during

treatment with biological agents

Original Article

Authors Abstract

Introduction: Chronic rhinosinusitis with
Pedro Marques Gomes nasal polyposis is a common pathology in
Unidade Local de Saúde de Matosinhos – Hospital Otorhinolaryngology, and the available therapeutic
Pedro Hispano, Portugal
options are medical and/or surgical. Medical
Diogo Cunha Cabral therapeutic options, in addition to topical and oral
Unidade Local de Saúde de Matosinhos – Hospital corticosteroid therapy, include biological agents.
Pedro Hispano, Portugal Three biological agents were recently approved for
the treatment of chronic rhinosinusitis with nasal
André Carção
Unidade Local de Saúde de Matosinhos – Hospital polyposis in Portugal, and are indicated in critically ill
Pedro Hispano, Portugal patients in whom the disease is not controlled with
topical nasal corticosteroid therapy, and in whom
Joana Barreto surgery (unless contraindicated) and/or systemic
Unidade Local de Saúde de Matosinhos – Hospital corticosteroid therapy did not provide adequate
Pedro Hispano, Portugal
control of the disease.
Ana Isabel Gonçalves Objectives: To propose a clinical evaluation protocol
Unidade Local de Saúde de Matosinhos – Hospital for patients undergoing biological treatment.
Pedro Hispano, Portugal Methods: A review of the relevant medical literature
was performed, namely from the two main
Paula Azevedo
Unidade Local de Saúde de Matosinhos – Hospital international working groups on this topic: European
Pedro Hispano, Portugal Position Paper on Rhinosinusitis and Nasal Polyps
2020 (EPOS) and European Forum for Research and
José Penêda Education in Allergy and Airway Diseases (EUFOREA).
Unidade Local de Saúde de Matosinhos – Hospital Results: The proposed protocol can be divided into
Pedro Hispano, Portugal
three phases: an initial phase involving collection of
Delfim Duarte demographic and clinical data, a second phase for
Unidade Local de Saúde de Matosinhos – Hospital evaluation of patient eligibility for biologicals based
Pedro Hispano, Portugal on well-defined admission criteria, and a third phase
with a proposal for follow-up and application of
Miguel Viana
Unidade Local de Saúde de Matosinhos – Hospital treatment efficacy and discontinuation criteria.
Pedro Hispano, Portugal, Conclusion: This clinical protocol presents a
proposition for the uniform collection of standardized
data to be used in clinical practice and for conducting
prospective and/or retrospective multicenter studies,
along with a proposition for follow-up and evaluation
of efficacy/failure of treatment with biological agents
in patients with chronic rhinosinusitis with polyposis.
Keywords: Chronic rhinosinusitis with polyposis,
Correspondence: Biological Agents, Clinical Protocol
Pedro Marques Gomes
pedrommarquesgomes@hotmail.com

Article received on December 24, 2022.
Accepted for publication on March 7, 2023.

Volume 61 . Nº2 . June 2023 157